Enzyme Engineering Research Scientist

DNA Script
DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using an enzymatic technology. The company aims at accelerating innovation in life science and technology through quick, decentralized solutions for laboratory work in life science and genomics. DNA Script's approach leverages nature's billions of years of evolution in synthesizing DNA to set a new standard for how nucleic acids are made and accelerate the adoption of synthetic biology across diverse disciplines such as biopharma, sustainable chemistry and data storage.

To date, DNA Script has raised over 58 M€ of financing, mostly through equity funding brought by prestigious players such as Illumina Ventures, LSP, Merck Ventures, Sofinnova Partners, BPIFrance, Kurma Partners and Idinvest. The company partners with leading institutions, in particular Institut Pasteur.

We are looking to assemble a team of world class, innovative and passionate people gathering their talents and skills to achieve one goal: unlock the power of DNA to write the future of life sciences. We offer the opportunity to join a dynamic, international and highly skilled team in a high-performance biotech startup. We offer a competitive benefits package (salary, equity, healthcare, meal vouchers and public transportation) along with a unique opportunity to work in the heart of Paris.

The role

DNA Script is looking for a talented individual to join the enzyme engineering team, in charge of helping the team to build highly performing enzyme variants for our DNA synthesis technology. The position will also set up new engineering projects to provide key technologies for the DNA synthesis process.


- Initiate, design and execute protein engineering projects
- Design, generate and screen libraries of enzyme variants using state-of-the-art techniques Purify proteins and plasmid DNA
- Develop and perform enzymatic activity tests
- Adapt/optimize existing workflows and develop new approaches to screen improved enzymes

Qualifications and experience


- Masters' or PhD Degree in Molecular Biology, Biochemistry or Chemistry
- Hands on' working experience in molecular biology, biochemistry, assay development, enzymology
- Expertise in state-of-the-art methods to engineer enzymes for improved stability, activity and selectivity.
- Familiarity with protein handling and purification
- Basic bioinformatics and protein structure analysis
- Ability to support multiple projects and to work closely with a multi-disciplinary scientific environment
- Fluent English speaker


- Familiarity with high throughput approaches
- in vitro protein expression and/or emulsion-based assays
- Experience with fluorescence-assisted cell sorting

- Job located in Kremlin-Bicêtre (Paris area)
- Start date: ASAP