Nucleotide Chemistry Research Assistant

DNA Script

DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using an enzymatic technology. The company aims at accelerating innovation in life science and technology through quick, decentralized solutions for laboratory work in life science and genomics. DNA Script's approach leverages nature's billions of years of evolution in synthesizing DNA to set a new standard for how nucleic acids are made and accelerate the adoption of synthetic biology across diverse disciplines such as biopharma, sustainable chemistry and data storage.

To date, DNA Script has raised over 58 M€ of financing, mostly through equity funding brought by prestigious players such as Illumina Ventures, LSP, Merck Ventures, Sofinnova Partners, BPIFrance, Kurma Partners and Idinvest. The company partners with leading institutions, in particular Institut Pasteur.

We are looking to assemble a team of world class, innovative and passionate people gathering their talents and skills to achieve one goal: unlock the power of DNA to write the future of life sciences. We offer the opportunity to join a dynamic, international and highly skilled team in a high-performance biotech startup. We offer a competitive benefits package (salary, equity, healthcare, meal vouchers and public transportation) along with a unique opportunity to work in the heart of Paris.

The role

DNA Script is looking for a talented research assistant in organic chemistry to join the Nucleotide Chemistry team. Under the supervision of the Modified Nucleotide Team Leader, you will be in charge of synthesizing multiple types of modified nucleosides/nucleotides. You will also perform quality analysis and purification using chromatography techniques (FC and HPLC) while maintaining detailed documentation of all work processes.


  • Synthesis of organic molecules/precursors needed for the production of modified nucleotides
  • Purification of organic molecules using column chromatography and reverse phase HPLC
  • Characterization of molecules (TLC, NMR, HPLC, LC/MS, …)
  • Conduct experiments following existing established protocols. Test as well new protocols
  • Hold a lab notebook and write detailed procedures and technical reports to consolidate the results and interpretation
  • Participate to the order and inventory of chemicals to maintain stock in the chemistry laboratory
  • Perform maintenance of certain equipment of the laboratory
  • Work according to GLP standards
Qualifications and experience


  • Bachelor Degree in the field of organic chemistry
  • Use of Microsoft Office and Chem Office
  • Ability to work independently and as part of a large multi-disciplinary team
  • Good understanding and speaking of English
  • Excellent organisation
  • Highly motivated candidate with passion for science
  • Willing to learn to new science areas
  • Experience on nucleoside/nucleotide chemistry


  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: ASAP
  • Permanent position (CDI)